Products related to Specificity:
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New Experimental Probes for Enzyme Specificity and Mechanism : Volume 685
New Experimental Probes for Enzyme Specificity and Mechanism, Volume 685, the latest release in the Methods of Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics including Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis, New Mechanistic Probes to Identify Novel Substrates for N-Myristoyltransferases, Phosphonate and a Fluorophosphonate Analogues of D Glucose 6 Phosphate as Active-Site Probes of 1L-Myo-Inositol 1 phosphate Synthase, Kinetic Mechanism of Nicotine-Degrading Enzyme Probed by Stopped-Flow Kinetic Analyses, Kinetics and Mechanism for Enzyme-Catalyzed Reactions of Substrate Pieces, and more. Additional chapters cover Kinetics and Mechanism for Reactions of Enzyme Pieces, Evaluation of allostery for the bienzyme assembly of a 3-deoxy-D-arabino heptulosonate-7-phosphate synthase and chorismate mutase, Recognition and Catalysis of Reactions of Chiral Substrates by Mandelate Racemase, Innovative and emerging modalities of EGFR kinase inhibitors, Characterization of the Aminoacrylate Intermediate of Tyrosine Phenol-Lyases, and much more.
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Ligand-Binding Basics : Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity
A concise and accessible textbook covering ligand-binding theory in chemistry, biology, and drug development In Ligand-binding Basics: Evaluating Intermolecular Affinity, Specificity, Stoichiometry, and Cooperativity, accomplished chemist Jannette Carey introduces ligand binding in a thorough and practical way for those new to the topic, as well as anyone seeking a connection between theory and experiment.Using a minimum of mathematical formalism, this book offers analytical rigor while remaining accessible to non-specialist practitioners.It provides readers with the skills they need to analyze their own binding data or published results, helping them develop an intuitive grasp of ligand-binding phenomena integrated with structural and thermodynamic understanding.Topics covered include: Application of the principles of equilibrium, mass action, and mass balance to derive the basic equations that describe all binding processesRecommended approaches for plotting and graphical analysis of binding dataStrategies for designing, analyzing, interpreting, and troubleshooting experiments from the perspective of ligand-binding theoryReview of selected examples that illustrate integration of structural and thermodynamic analysis Perfect for students and educators in chemistry, biochemistry, molecular biology, and pharmaceutical science, Ligand-binding Basics will also appeal to practitioners who aim to study ligand binding in any molecular system.
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Autobiographical Memory Specificity and Psychopathology : A Special Issue of Cognition and Emotion
It has been repeatedly demonstrated that depression and reported history of trauma are associated with a difficulty in retrieving specific autobiographical memories, a phenomenon called overgeneral memory (Williams & Broadbent, 1986).Over the past twenty years there has been a stimulating progression in knowledge in this field, and it is clear that the topic has a considerable level of importance, both from a theoretical and clinical perspective.This Special Issue is intended to further advance this field which lies at the heart of the cognition-emotion interface.Papers published in this Issue address key issues relating to the underlying mechanisms and aetiology of overgeneral autobiographical memory, providing a state-of-the-art and pushing the field forward.
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All Services, All the Time : How Business Services Serve Your Business
This book takes the position that organizations, such as businesses, government agencies, etc. form a special class of living system. As such they come into being, live through lifecycle stages, and can experience organizational health and various forms of organizational illness along the way.If the latter is frequent or extended, such organizations often die an untimely death.A services perspective can go a long way to combat this outcome and assist in maintaining organizational health.Allowing this perspective to permeate an organization induces a consideration of its genuine value and leads to a greater understanding of the breadth of stakeholders who are the beneficiaries of it. Productivity and services in an organization are symbiotic—and must be so in order to achieve the balance that is key to the health of each organization.A services perspective illuminates as well the pivotal role that business-to-business service providers play in ensuring that balance is achieved and maintained.This book explores these factors from the point of view of the business leader and anyone concerned with the health of any organization.
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What are substrate specificity and activity specificity using the example of restriction enzymes?
Substrate specificity refers to the ability of an enzyme to recognize and bind to a specific substrate molecule. In the case of restriction enzymes, they have substrate specificity for particular DNA sequences, known as recognition sites. For example, the restriction enzyme EcoRI recognizes and binds to the DNA sequence GAATTC. Activity specificity, on the other hand, refers to the specific chemical reaction that an enzyme catalyzes. In the case of restriction enzymes, their activity specificity is to cleave the DNA at specific recognition sites. For example, EcoRI cleaves the DNA at the GAATTC sequence. In summary, substrate specificity refers to the ability of an enzyme to recognize and bind to a specific substrate molecule, while activity specificity refers to the specific chemical reaction that the enzyme catalyzes. In the case of restriction enzymes, they have substrate specificity for specific DNA sequences and activity specificity to cleave the DNA at those sequences.
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What is the actual difference between catalytic specificity and substrate specificity in enzymes?
Catalytic specificity refers to the ability of an enzyme to catalyze a specific chemical reaction, while substrate specificity refers to the ability of an enzyme to bind to a specific substrate. In other words, catalytic specificity is about the type of reaction that an enzyme can catalyze, while substrate specificity is about the specific molecule that an enzyme can bind to and act upon. Enzymes can have different levels of specificity for both their catalytic activity and their substrate binding, which allows them to carry out specific functions in the cell.
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What is the substrate specificity of enzymes?
The substrate specificity of enzymes refers to the ability of an enzyme to recognize and bind to a specific substrate molecule. Enzymes are highly specific in their interactions with substrates, as they have active sites that are uniquely shaped to accommodate specific substrates. This specificity ensures that enzymes only catalyze specific reactions and do not interact with other molecules in the cell. Substrate specificity is crucial for the efficiency and regulation of biochemical reactions in living organisms.
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What is the group specificity of enzymes?
Group specificity of enzymes refers to the ability of an enzyme to act on a specific functional group within a substrate molecule. This means that the enzyme can only catalyze a reaction involving a particular functional group, such as an alcohol or an amine. Enzymes with group specificity are highly selective and only interact with substrates that contain the specific functional group that they are designed to act upon. This specificity is important for the regulation and control of biochemical pathways in living organisms.
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Enquiries of Local Authorities and Water Companies: A Practical Guide
As an essential part of the conveyancing process, the purchaser of property or land carries out a search at the local authority offices to discover if there are any planning; environmental health; highways or water restrictions appertaining to the property or land to be purchased. The new edition of this popular work provides a clear and concise commentary on the new Forms Con29 and Con29O and on the current version of Form Con29DW (Water and Drainage Enquiries).For the first time Form Con 29 now has enquiries relating to surface water drainage schemes, heritage partnership agreements, flood and coastal erosion risk management, community infrastructure levy, assets of community value, flood consents and land drainage consents. The sixth edition of this book examines each enquiry in turn, and clearly sets out the relevant and up-to-date legal position with sources and references.The authors then provide a summary of the implications of any reply by the local authority or water company concerned, positive or negative, so that a prospective purchaser can make a balanced decision as to whether to proceed with the purchase. Enquiries of Local Authorities and Water Companies: A Practical Guide provides an invaluable reference for the conveyancing practitioner, local land charges officer or estate agent.
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Everyone's Business : What Companies Owe Society
Business is political. What are the ethics of it? Businesses are political actors. They not only fund political campaigns, take stances on social issues, and wave the flags of identity groups – they also affect politics in their everyday hiring and investment decisions.As a highly polarized public demands political alignment from the powerful businesses they deal with, what’s a company to do? Amit Ron and Abraham Singer show that the unavoidably political role of companies in modern life is both the fundamental problem and inescapable fact of business ethics: corporate power makes business ethics necessary, and business ethics must strive to mitigate corporate power. Because of its economic and social influence, Ron and Singer forcefully argue that modern business’s primary social responsibility is to democracy.Businesses must work to avoid wielding their power in ways that undermine key democratic practices like elections, public debate, and social movements.Pragmatic and urgent, Everyone’s Business offers an essential new framework for how we pursue profit—and democracy—in our increasingly divided world.
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Local Welfare and the Organization of Social Services : Local Area Planning in the Lombardy Region
This book discusses local area planning in the Lombardy region of Italy.The book provides valuable insights about the development of local welfare systems and the territorial organization of social services through the analysis of the evolution of the Local Area Plan, which lies at the intersection of sub regional governance and of social services delivery models.Using Lombardy as a case study, this brief analyzes the structural conditions influencing the establishment of Local Area Plans, their effect on inter-municipal cooperation, and the need for possible reforms.The book is organized as follows: the first chapter presents a reconstruction of the national and regional framework, analyzing the structure of ties and opportunities within which Local Area Plans are called to act.The second chapter provides a review of the extant literature on Local Area Plans and introduces the theoretical framework used by the volume.The third chapter details legislation introduced in Lombardy to reform the governance structure of Local Area Plans by supporting a process of reorganization and aggregation.The fourth chapter presents some cases of Local Area Plan aggregation.The final chapter presents the conclusion and some brief considerations about the future of social planning.Providing an empirical analysis of local service delivery, this book will be useful to scholars and practitioners interested in public administration, welfare, local government, non-profit and public organizations, and management.
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Delivery by Design : Intermunicipal Contracting, Shared Services, and Canadian Local Government
Municipalities in Canada have an array of servicing options available to them when producing or delivering local services, such as water, public transit, and waste collection, including in-house provision or privatization.However, services may also be contracted or jointly-delivered with neighbouring municipalities – a practice some local governments are increasingly gravitating towards. Delivery by Design sheds light on this practice in Canadian local government by examining three crucial questions: Why do municipalities cooperate?What is being shared or contracted with other governments? And what leads to successful or unsuccessful relationships between municipalities?The book finds that Canadian municipalities are cooperating fairly regularly, but are doing so in a small number of policy areas, mainly emergency and administrative services.Zachary Spicer examines these types of relationships, explaining how they will be crucial in the future as local services are increasingly shared or jointly delivered by municipal governments. Relying on extensive data and document collection, surveys, and a series of primary interviews with local decision-makers, Delivery by Design explores the nature of interlocal collaboration in Canada, mapping out a relatively understudied process in local governance.
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What is the biosubstrate specificity of bonds?
The biosubstrate specificity of bonds refers to the ability of enzymes to selectively bind to specific substrates and catalyze specific chemical reactions. Enzymes have specific active sites that are complementary to the shape and chemical properties of their substrates, allowing them to form temporary bonds and facilitate the conversion of substrates into products. This specificity is crucial for the regulation of biochemical pathways and the overall functioning of biological systems. It ensures that the right reactions occur at the right time and in the right place within the cell.
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What is the specificity of enzymes on substrates?
Enzymes are highly specific in their interactions with substrates, meaning that each enzyme typically catalyzes a specific chemical reaction with a specific substrate. This specificity is due to the unique three-dimensional shape of the enzyme's active site, which is complementary to the shape and chemical properties of its specific substrate. The enzyme-substrate interaction is often compared to a lock and key, where the enzyme (lock) can only bind to its specific substrate (key) due to their precise matching shapes and chemical properties. This specificity ensures that enzymes can efficiently catalyze specific reactions without interfering with other cellular processes.
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What does the term cell type specificity mean?
Cell type specificity refers to the unique characteristics and functions of a particular type of cell within an organism. It means that certain cells are specialized to perform specific tasks or functions within the body, and they have distinct molecular and structural features that enable them to carry out these functions. This specificity allows for the coordination and regulation of various physiological processes within the organism, as different cell types can perform their specialized roles in a coordinated manner. Understanding cell type specificity is important for studying the development, function, and dysfunction of different tissues and organs in the body.
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Could you please provide an urgent response regarding specificity of action?
Specificity of action refers to the ability of a treatment or intervention to target a particular problem or condition without affecting other parts of the body. It is important to consider the specificity of action when choosing a treatment to ensure that it effectively addresses the intended issue without causing unnecessary side effects or harm to other areas. It is also important to consult with a healthcare professional to determine the most appropriate and specific treatment for a particular condition.
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